Several moderate-very strenuous trails leave from the Death Canyon Trailhead. To access trails, drive down the Moose-Wilson road and follow signs to the Death Canyon Trailhead. The Moose-Wilson Road is closed to RVs and trailers and occasionally has closures. The Death Canyon Trailhead is located one mile down a rutted, dirt road. The road is not recommended for vehicles with low clearance. Exercise caution when driving down the Death Canyon Road and pull fully off of the road if parking on the shoulder.

Multiple hikes from Death Canyon include access to backcountry campsites. A backcountry permit is required for all overnight stays in the backcountry.

Always be prepapred when hiking in Grand Teton. Carry water for every member of your group, be alert to your surroundings, and understand your limitations on distance and elevation gain. Several trails from the Death Canyon Trailhead can hold snow until mid-July. Hikers should use caution when traveling over snow and not attempt trails unless they have previous snow experience and the proper equipment. Wildlife—such as bears—is commonly active in the area. Never approach a wild animal. To check current trail conditions and bear activity, stop at a visitor center to talk with a ranger.