There are numerous activities along the Natchez Trace Parkway that are accessible to people with varying abilities. From paved overlooks and trails, to visitor centers there are opportunities to get out of your car and experience the Parkway.
The following list of accessible facilities and features may help you plan your trip
| Milepost | Facility | Services Available |
| 15.5 | Mount Locust | Restroom, exhibit shelter, and grounds of historic house |
| 17.5 | Coles Creek | Restroom, designated picnic table |
| 54.8 | Rocky Springs | Restrooms in campground, designated campsite with picnic table |
| 102.4 | Parkway Information Cabin |
Restrooms, visitor center, and multi-use paved recreational trail |
| 122.6 | River Bend | Restrooms, designated picnic table |
| 154.3 | Holly Hill |
Restrooms, designated picnic table |
| 159.9 | Kosiusko Visitor Center | Restrooms, visitor center |
| 193.1` | Jeff Busby | Restrooms, designated campsite with picnic table |
| 232.4 | Bynum Mounds | Loop trail to exhibit shelter and mounds, slight grade |
| 233.2 | Witch Dance | Restrooms, designated picnic table |
| 261.8 | Chickasaw Village | Exhibit shelter |
|
266 |
Parkway Visitor Center | Restroom, visitor center, nature trail. The park film is closed captioned. |
| 327.3 | Colbert Ferry | Restroom at boat launch, designated picnic table |
| 364.5 | Glenrock Branch | Restrooms |
| 377.8 | Jacks Branch | Restrooms |
| 385.9 | Meriwether Lewis | Restrooms, visitor center (hours vary), interpretive trail, designated campsite with picnic table |
| 407.7 | Gordon House Historic Site | Trail to interpretive exhibits near home |
| 427.9 | Garrison Creek | Restooms |
In addition to the above locations, each pullout along the Parkway has a routed sign that can be read from the vehicle. Interpretive signs at trailheads and parking areas are also wheelchair accessible.