Whichever way you were traveling on the trail it was a long, hard trip. Yes, traders could make a lot of money, but they could also lose all their money. Or even die. Thunderstorms and hot summers on the prairie made the trip difficult for both men and animals. Running out of food and water was another problem. One Santa Fe Trail traveler, Hezekiah Brake, wrote in 1858, "I wondered, too, if the breezes that swept this high table-land, could speak, what tales of snowstorms, of sand storms, of freezing and starving cattle, or perishing men, it would whisper in our ears."
Indian attacks were also common. The trail went through the home of several Plains Indians tribes. These tribes included the Kiowa Apache, Comanche, Arapaho and Cheyenne. Indians often attacked the wagon trains, taking supplies and horses. Indians also attacked to try and stop travel on the trail. Trail travelers scared away game, cut down trees and dirtied water supplies the Indians used. The more people traveled the trail, the more Indians attacked them.