Below are driving directions to follow The Oregon National Historic Trail west through Wyoming, from Nebraska to Idaho. A simple map showing the general route is below the directions.
- Take U.S. Route 26 west to Interstate 25.
- Turn north onto Interstate 25.
- Take Interstate 25 west to State Route 220.
- Turn west onto State Route 220.
- Take State Route 220 to U.S. Route 287.
- Turn west onto U.S. Route 287.
- Take U.S. Route 287 west to State Route 28.
- Turn West onto State Route 28.
- Take State Route 28 west to State Route 372.
- Turn southeast onto State Route 372.
- Take State Route 372 east to Interstate 80.
- Turn west onto Interstate 80.
- Take Interstate 80 west to State Route 412.
- Turn north onto State Route 412.
- Take State Route 412 to U.S. Route 189.
- Turn north onto U.S. Route 189.
- Take U.S. Route 189 north to U.S. Route 30.
- Turn west onto U.S. Route 30.
Total original route miles in Wyoming: 491