Below are driving directions to follow the Oregon National Historic Trail west through Kansas, from Missouri to Nebraska. A simple map showing the general route follows the directions.
- Take Interstate 435 south from Kansas City to State Route 10.
- Turn west onto State Route 10.
- Take State Route 10 west to U.S. Route 59.
- Turn north onto State Route 59.
- Take State Route 59 north to Interstate 70.
- Turn west onto Interstate 70.
- Take Interstate 70 to U.S. Route 40.
- Turn west onto U.S. Route 40.
- Take Interstate 40 west to Interstate 70.
- Turn west onto Interstate 70.
- Take Interstate 70 west to Exit 346 Willard Dover Rd.
- Turn north onto Willard Dover Rd.
- Take Willard Dover Rd. north to U.S. Route 24.
- Turn west onto U.S. Route 24.
- Take U.S. Route 24 west to State Route 99.
- Turn north onto State Route 99.
- Take State Route 99 north to State Route 9.
- Turn west onto State Route 9.
- Take State Route 9 west to U.S. Route 77.
- Turn north onto State Route 77.
- Take State Route 77 to U.S. Route 36.
- Turn west onto U.S. Route 36.
- Take U.S. Route 36 west to State Route 148.
- Turn north onto State Route 148 into Nebraska.
Total original route miles in Kansas: 165