De Soto National Memorial is easily accessible by plane, automobile, and boat.
Plane Two major airports are located with a 50 minute drive of the park:
De Soto National Memorial's Street Address:
From I-275 exit 5, follow US-19 into Bradenton. Turn west onto State Road 64, and proceed approximately five miles to 75th Street West. Turn right (north) onto 75th Street West, and proceed two and one half mile to the park entrance and the terminus of 75th Street/ De Soto Memorial Highway.
From Cortez Ave travel west to 75th St. W. turn right. Travel north on 75th St. W. approximately 4 miles to northern terminus. 75th St. W. turns into De Soto Memorial Hwy and will dead end into
Boaters may access the park via the Manatee River. A small cove east (up river) of De Soto Point offers a temporary anchorage sheltered from south winds. Small craft may be beached at the cove, but boaters may not tie to protected vegetation including mangroves nor to park equipment including signs and benches.
De Soto National Memorial does not have a boat ramp.