Wright Brothers National Memorial is located at mile post 7.5 on U.S. Highway 158, Kill Devil Hills, North Carolina.

• From the North - Follow I-95 South to Richmond, Va. Take I-64 East toward Norfolk/Virginia Beach, Va. Take I-64 or I-664 to Chesapeake, Va. From I-64, take Exit 291B to Route 168, the Chesapeake Expressway.* Once in North Carolina, Route 168 turns into U.S. 158 East. Follow U.S. 158 through Kitty Hawk to Kill Devil Hills, N.C. *Chesapeake Expressway is a toll road which costs $2.00 each way. 
• From the West - Via I-95 into North Carolina. Take U.S. 64 East toward Rocky Mount. Follow U.S. 64 east through Williamston and Plymouth. From Plymouth, continue east to Nags Head and the junction of U.S. 158 through Nags Head to Kill Devil Hills, N.C.
• From the South - Coming from South Carolina, take I-95 to Wilson, N.C. Take US-264 East through Greenville and Washington. From Washington, take State Route 30 to Plymouth, and follow U.S. 64 east to Nags Head. Continue on U.S. 158 through Nags Head to Kill Devil Hills, N.C.

The Norfolk, Va. Airport (100 miles distance) and the Raleigh-Durham, N.C. Airport (200 miles distance) offer commercial airline service.

The Manteo, N.C. Airport (MQI) services private aircraft.

First Flight Airstrip located at the Memorial is available for air travelers. Use is limited to daylight hours.