Wright Brothers National Memorial is located at mile post 7.5 on U.S. Highway 158, Kill Devil Hills, North Carolina.

• From the North - Follow I-95 South to Richmond, VA. Take I-64 East toward Norfolk/Virginia Beach, Va. Take I-64 or I-664 to Chesapeake, Va. From I-64, take Exit 291B to Route 168, the Chesapeake Expressway.* Once in North Carolina, Route 168 turns into US-158 East. Follow US-158 through Kitty Hawk to Kill Devil Hills, NC. *Chesapeake Expressway is a toll-road which costs $2.00 each way. 
• From the West - Via I-95 into North Carolina. Take US-64 East toward Rocky Mount. Follow US-64 East through Williamston and Plymouth, NC. From Plymouth, NC keep going east to Nags Head, NC and the junction of US-158 through Nags Head to Kill Devil Hills, NC.
• From the South - Coming from South Carolina, take I-95 to Wilson, NC. Take US-264 East through Greenville and Washington, NC. From Washington, take State Route 30 to Plymouth, NC and follow US-64 East to Nags Head, NC. Continue on US-158 through Nags Head to Kill Devil Hills, NC.

The Norfolk, VA Airport (100 miles distance) and the Raleigh-Durham, NC Airport (200 miles distance) offer commercial airline service.

The Manteo, NC Airport (MQI) services private aircraft.

First Flight Airstrip located at the Memorial is available for air travelers. Use is limited to daylight hours.