Constructed ca. 1851 by Griffin Taylor, a wealthy Frederick County agriculturist, the Worthington House is typical of the farmhouses favored by substantial farmers in Frederick County. Originally known as "Clifton Farm," the house and surrounding 300 acres adjacent to the Monocacy River were sold to John T. Worthington in 1862. Renaming his new property "Riverside Drive and Farm," John Worthington enjoyed success in farming until his death in 1905. The farm remained in the Worthington family until 1953.
During the Battle of Monocacy on July 9, 1864, Confederate troops crossed the Monocacy River onto the Worthington Farm. From the farm fields, the Confederates initiated three advances toward the Union line positioned at the neighboring Thomas Farm.