Nicodemus National Historic Site is located in northwestern Kansas on Highway 24 between Hill City and Stockton.

From Denver, take Interstate 70 east to Colby, Kansas (approximately 4 hours), then exit on Highway 24 to Nicodemus (approximately 1.5 hours).

From Kansas City take Interstate 70 west to Hays (approximately 4.5 hours), and exit at Highway 183 north to Stockton, then west on Highway 24 to Nicodemus (approximately 1 hour).

From Omaha take Interstate 80 toward Kearney to exit 257.  Nicodemus is approximately 2 hours from Kearney.  Take exit 257 toward Holdrege Highway 183 toward Hill City, KS.  From Hill City take Highway 24 to Nicodemus (approximately 15 minutes).

The Visitor Center (Township Hall) is south of the Roadside Park off Highway 24.