General Greely was away in the early hours of April 18, 1906, when the Funstons awoke to feel their home shaking on its foundation. When the extent of the damage of the infamous San Francisco earthquake became obvious, General Funston immediately ordered troop mobilization and took personal command of local law enforcement and relief efforts. Though acting without explicit state or national authority, Funston worked quickly to establish communications, sanitation, medical facilities, basic accommodations, and general order in the ravaged city.
As her husband organized relief efforts, Eda worked tirelessly to assist the victims of the earthquake. While fires spread throughout San Francisco, Eda assisted Dora Thompson, the Head Nurse at Letterman Hospital, in caring for the injured. She also directed a nurses' corps at the Presidio. In the aftermath of San Francisco’s greatest natural disaster, no family was more influential than the Funstons in the salvation of the city.