Last updated: January 4, 2026
Person
Isaac D. Knight
Courtesy of Delmar and Joan Hooley
Isaac Donaldson Knight, an experienced medical professional, served was the Chief Surgeon of the US Army of West Virginia during the 1864 Shenandoah Valley Campaign.
Early Life
At the age of four, the Knight family moved to Philadelphia, Pennsylvania, where Isaac was raised and educated as a Quaker. Knight graduated with a Doctor of Medicine in 1837 from the University of Pennsylvania. The following year he moved to Galveston, Texas where he married Ann Catherine Hoff. They had three children, Henry, Mary, and Bernardo. Medical Career
Doctor Knight’s medical profession took him to many places, including several cities in Mexico. When war broke out between Mexico and the United States in 1846, he returned to Galveston and began working for the US Army. In 1855 Knight and his family moved back to Philadelphia. He established a private medical practice in the city.Civil War Service
Knight enlisted as a surgeon in the 91st Pennsylvania Volunteer Infantry in 1861. In August of 1862, the regiment was attached to the Federal Army of the Potomac 5th Corps. Although the 91st Pennsylvania was not engaged at Antietam, Knight was present at field hospitals afterwards. Antietam remains the bloodiest single day battle in American history. At various points during the battles of Chancellorsville and Gettysburg, Knight served as the brigade level, and division level, medical director.In the Shenandoah Valley
On June 30, 1864, Knight was appointed as a surgeon for the US Army of West Virginia operating near Virginia's Shenandoah Valley. He was assigned to Captain Henry DuPont’s artillery battalion and witnessed extensive combat during the 1864 Shenandoah Valley campaign.During the Battle of Cedar Creek (October 19, 1864), Knight was captured by the attacking Confederates and taken prisoner. As the Confederates retreated from the battlefield in the afternoon, Knight accompanied the ambulance wagon of mortally wounded Confederate General Stephen Ramseur. As they moved south on the Valley Pike it became apparent that the wagon would be overtaken by US cavalry. Major Robert R. Richardson, Ramseur's medical officer, surrendered to Knight on the general's behalf. Knight ordered that Ramseur be taken to Belle Grove Plantation so he could receive additional medical care. Ramseur died in the plantation house the next day.