Organized at Richmond and Indianapolis, Ind., and mustered in September 3, 1862. Ordered to Covington, Ky., September 8, and duty in the defences of Covington and Cincinnati, Ohio, during Kirby Smith's threatened attack on Cincinnati. Moved to Point Pleasant, W. Va., October 1. Attached to 3rd Brigade, Kanawha Division, District of West Virginia, Dept. of Ohio, to November, 1862. District of Eastern Kentucky, Dept. of Ohio, to February 18, 1863. 2nd Brigade, Baird's 3rd Division, Army of Kentucky, Dept. Ohio, February, 1863. Baird's Division, Franklin, Tenn., Dept. of the Cumberland, to June, 1863. 1st Brigade, 1st Division, Reserve Corps, Dept. of the Cumberland, to October, 1863. 2nd Brigade, 1st Division, 4th Army Corps, Army of the Cumberland, to August, 1864. 3rd Brigade, 1st Division, 4th Army Corps, to June, 1865.
Moved from Point Pleasant, W. Va., to Guyandotte October 13, 1862, and duty there till November 14. Ordered to Kentucky November 14. Duty at Catlettsburg and Cassville, Ky., till February 7, 1863. Moved to Nashville, Tenn., February 7-20, thence to Franklin, Tenn., March 5, and duty there till June 3. Pursuit of Van Dorn March 9-12. Repulse of Van Dorn's attack on Franklin April 10. Moved to Triune June 3. Repulse of Forest's attack on Triune June 11. Middle Tennessee or Tullahoma Campaign June 23-July 7. Occupation of Shelbyville July 1. At Wartrace till August 12. Chickamauga (Ga.) Campaign August-September. Battle of Chickamauga September 19-21. Siege of Chattanooga, Tenn., September 24-October 26. Near Chattanooga October 2. Reopening Tennessee River October 26-29. At Whiteside till February, 1864. Near Kingston December 4, 1863. Demonstration on Dalton, Ga., February 22-27, 1864. Tunnel Hill, Buzzard's Roost Gap and Rocky Faced Ridge February 23-25. Atlanta (Ga.) Campaign May 1 to September 8. Tunnel Hill May 6-7. Demonstrations on Rocky Faced Ridge and Dalton May 8-13. Buzzard's Roost Gap May 8-9. Battle of Resaca May 14-15. Near Kingston May 18-19. Near Cassville May 19. Advance on Dallas May 22-25. Operations on line of Pumpkin Vine Creek and battles about Dallas, New Hope Church and Allatoona Hills May 25-June 5. Operations about Marietta and against Kenesaw Mountain June 10-July 2. Pine Hill June 11-14. Lost Mountain June 15-17. Assault on till September 26. Moved to Memphis, thence march Chattahoochie River July 5-17. Peach Tree Creek July 19-20. Siege of Atlanta July 22-August 25. Flank movement on Jonesboro August 25-30. Battle of Jonesboro August 31-September 1. Lovejoy Station September 2-6. Operations against Hood in North Georgia and North Alabama September 29-November 3. Nashville Campaign November-December. Columbia, Duck River, November 24-27. Battle of Franklin November 30. Battle of Nashville December 15-16. Pursuit of Hood to the Tennessee River December 17-28. Moved to Huntsville, Ala., and duty there till March, 1865. Operations in East Tennessee March 15-April 22. At Nashville, Tenn., till June. Mustered out June 14, 1865. Recruits transferred to 57th Indiana Infantry.
Regiment lost during service 5 Officers and 82 Enlisted men killed and mortally wounded and 2 Officers and 145 Enlisted men by disease. Total 234.