Organized at Clinton and mustered in August 6, 1862. Moved to Sedalia, Mo., August 11. Attached to District of Southwest Missouri, Dept. of Missouri, to October, 1862. 1st Brigade, 2nd Division, Army of the Frontier, Dept. of Missouri, to June, 1863. District of Southwest Missouri, Dept. of Missouri, to October, 1863. District of the Frontier, Dept. of Missouri, to December, 1863. 2nd Brigade, District of the Frontier, Dept. of Missouri, to January, 1864. 2nd Brigade, District of the Frontier, 7th Army Corps, Dept. of Arkansas, to March, 1864. 1st Brigade, District of the Frontier, 7th Corps, to January, 1865. 1st Brigade, 3rd Division, 7th Corps, to July, 1865.
Moved to Springfield, Mo., arriving September 13, 1862. Operations in Southwest Missouri September to November, 1862. Duty at Springfield, Mo., November 14, 1862, to September 22, 1863. Defence of Springfield January 7-8, 1863. Affair at Quincy September 4, 1863 (Detachment). Expedition from Springfield into Arkansas and Indian Territory September 7-19. Near Enterprise September 15. Operations against Shelby September 22-October 31. Arriving at Fort Smith October 31. Action at Cross Timbers October 15-16 (Cos. "D" and "F"). Garrison duty at Fort Smith, Ark., till March, 1864. Steele's Campaign against Camden March 22-May 15. Prairie D'Ann April 9-12. Moscow April 13. Poison Springs April 18. Jenkins Ferry, Saline River, April 30. Garrison duty at Fort Smith till July, 1865. (4 Cos. at Van Buren February 26 to July 6, 1865.) Ordered to Little Rock and mustered out July 20, 1865.
Regiment lost during service 2 Officers and 33 Enlisted men killed and mortally wounded and 1 Officer and 131 Enlisted men by disease. Total 167.