Below are driving directions to follow the Pony Express National Historic Trail west through Utah, from Wyoming to Nevada. A simple map showing the general route is below the directions.

 From the Wyoming - Utah state border:

1. Take Interstate 80 west to Interstate 84.
2. Turn west onto Interstate 84.
3. Take Interstate 84 west to State Route 65.
4. Turn south onto State Route 65.
5. Take State Route 65 south to Interstate 80.
6. Turn west onto Interstate 80.
7. Continue west on Interstate 80 through Salt Lake City and to Nevada.

Total original route miles in Utah: 241