Below are driving directions to follow the Oregon National Historic Trail to Oregon, from Idaho, and along the Columbia River. A simple map showing the general route is below the directions.

To follow the Oregon National Historic Trail to Oregon, from Idaho:

1. Take State Route 20/26 north to State Route 201.
2. Turn west onto State Route 201.
3. Take State Route 201 west to Interstate 84.
4. Turn west onto Interstate 84.
5. Take Interstate 84 west to U.S. Route 197.
6. Turn south onto U.S. Route 197 at The Dalles.
7. Take U.S. Route 197 south to State Route 48.
8. Turn west onto State Route 48.
9. Take State Route 48 west to State Route 35.
10. Turn west onto State Route 35.
11. Take State Route 35 west to U.S. Route 26.
12. Turn west onto U.S. Route 26.
13. Take U.S. Route 26 west to State Route 211.
14. Turn west onto State Route 211.
15. Take State Route 211 west to State Route 224.
16. Turn west onto State Route 224.
17. Take State Route 224 west to State Route 213.
18. Take State Route 213 to Oregon City and the trail's end.

To follow the trail along the Columbia River:

1. Take State Route 20/26 north to State Route 201.
2. Turn west onto State Route 201.
3. Take State Route 201 west to Interstate 84.
4. Turn west onto Interstate 84.
5. Continue on Interstate 84 west through The Dalles to Interstate 5.
6. Turn south onto Interstate 5.
7. Take Interstate 5 south to Oregon City and the trail's end.

Total original route miles in Oregon: 524