De Soto National Memorial's Street Address:
8300 De Soto Memorial Hwy
Bradenton, Florida 34209

Driving Directions:
From I-75 Take exit 220 (SR 64/Manatee Ave) Gulf Beaches exit. Travel west on SR 64 for approximately 12 miles to 75th St. W. Turn right onto 75th St. W. travel north approximately 2 miles to the northern terminus 75th St. W. turns into De Soto Memorial Hwy and dead ends into the park.

From I-275 exit 5, follow US-19 into Bradenton. Turn west onto State Road 64, and proceed approximately five miles to 75th Street West. Turn right (north) onto 75th Street West, and proceed two and one half mile to the park entrance and the terminus of 75th Street/ De Soto Memorial Highway.

From Cortez Ave travel west to 75th St. W. turn right. Travel north on 75th St. W. approximately 4 miles to northern terminus. 75th St. W. turns into De Soto Memorial Hwy and will dead end into park.