De Soto National Memorial is comprised of approximately 26 acres in Manatee County on the west coast of central Florida. Situated on a spit of land at the mouth of the Manatee River at its confluence with Tampa Bay, the park has over 3000 feet of shoreline. Roughly 80% of the park is mangrove swamp with the remainder consisting of pine flatlands and mixed hardwoods, remnant shell ridges, and deposited dredge material from the adjacent Manatee River.