In 1860 Grant and his family moved to Galena.

In his memoirs, Grant wrote of the 1860 election:

"It was evident, from the time of the Chicago nomination to the close of the canvass, that the election of the Republican candidate would be the signal for some of the Southern States to secede. I still had hopes that the four years which had elapsed since the first nomination of Presidential candidate by party distinctly opposed to slavery extension, had given time for the extreme pro-slavery sentiment to cool down; for the Southerners to think well before they took the awful leap which they had so vehemently threatened. But I was mistaken."

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