One Health and Disease: Hantavirus

Small, grey mouse sitting in a nest of brown grass
The deer mouse is native to most parks in the U.S.

NPS Photo/Channel Islands National Park.


Hantaviruses exist worldwide, causing infections in rodents and rarely in humans. The virus, which is primarily transmitted from infected rodents, can cause severe health outcomes in humans.

General Hantavirus Information

Geographic Distribution

Many different hantaviruses exist throughout North America, with four main strains causing human illnesses throughout the continental US. In the US, the majority of human illnesses have occurred in rural residents of western states.


Certain species of rodents serve as the primary hosts for hantaviruses. The deer mouse (Peromyscus maniculatus) is the primary host in the Western US while the white-footed mouse is the primary host in the eastern US. The rice and cotton rat also serve as hosts in the southeastern US. Deer mice are responsible for the majority of human infections.

The virus responsible for disease in the United States cannot be transmitted from human to human. Pets cannot transmit virus to humans or become sick.


Hantaviruses are shed in the urine, feces, and saliva of infected rodents. Infectious particles are then inhaled or ingested by a susceptible host. Rodents can also become infected through bites of other infected rodents, and humans can be infected through such bites.

Staying or working in enclosed spaces with mice increases the risk for human infection by inhaling contaminated dust.

Signs and Symptoms

Rodent hosts infected with hantavirus typically do not show any clinical signs, although they may have a shorter lifespan.

Signs of human infection are typically present 1-8 weeks after exposure and can include:

  • Fever

  • Muslce and head aches

  • Nausea and vomiting

  • Severe respiratory disease

  • Shortness of breath


If you have any of the symptoms of hantavirus and were recently exposed to rodents or their droppings, consult your healthcare provider.

There is no specific treatment for hantavirus but supportive care can improve clinical outcome.

Prevention and Control

In wildlife, scientists have shown that natural habitats with more species of rodents and natural predators have lower rates of hantavirus infection in deer mice populations, so protecting natural ecosystems might be important to preventing hantavirus spread.

  • Avoid contact with rodents and their droppings and clean promptly when found.

  • Prevent rodents from entering buildings– seal any gap greater than one quarter of an inch.

  • Properly store and dispose of food and trash, keep pet food in sealed containers, and keep vegetation at least 18 inches from buildings.

Official logo of the One Health program

NPS Graphic.

One Health and Hantavirus

Human impacts on the environment, including land development, climate change, and the removal of natural predators, are affecting mouse behavior and habitats. Some of these changes to the land, air, and water promote the transmission and spread of diseases such as hantavirus in mouse populations and can thereby increase human risk.

By protecting natural environments and their ecological properties and processes, we can help protect ourselves from hantavirus – this is One Health in action.

A person sprays a plastic bottle of solution at a dead mouse in a trap
Soak mouse, trap, and any droppings or urine with EPA registered disinfectant and allow to sit for 10 minutes before wiping up.

NPS Photo.

The following information is intended for circumstances involving light infestations and rodent trapping and/or encountering sparse or incidental rodent droppings in active human areas. Consult public health and safety specialists before cleaning areas with a large rodent concentration and droppings, especially in enclosed, non-ventilated areas. These require more stringent personal protective measures and approved respirator fit testing. Consult a public health and safety officer if you are unsure the infestation is light or heavy.

Directions for cleaning up a light infestation

1. Open windows to ventilate rooms for at least 30 minutes prior to cleaning. Leave the area during this period. Direct sunlight also helps to inactivate the virus. Take care not to stir up dust and NEVER vacuum.

2. Dilute disinfectant to obtain either a 1:10 bleach solution or obtain a 5% LysolTM solution and add to spray canister. Diluted solutions MUST be made fresh daily or they will be ineffective. Be sure chosen product is labeled as a disinfectant, has an EPA registration number, and consider how the product may affect the surface to be cleaned prior to use.

3. Make sure gloves are worn when tending traps or sites. Re-usable gloves must be disinfected after use.

4. Leave in place and soak the droppings, nest, rodent, and/or trap thoroughly with disinfectant solution and spray at least a 2-foot area around the trap. Spray/soak any associated droppings and urine. Allow to sit undisturbed for at LEAST 10 minutes.

5. Invert a plastic bag over the gloved hand, unfold it over the droppings and/or trap and rodent carcass as you pick up the trap and rodent carcass and tie-off or seal bag. Seal and place bag into another plastic bag and seal, always keep rodent at an arm’s length and take care not to stir up dust.

6. Respray any exposed droppings with the disinfectant and then use a disposable paper towel to clean up any visible droppings.

7. Spray gloves (while on hands) and, if disposable, place in plastic bag, seal, and dispose. If a respirator and goggles were worn, lay in direct daylight for at least an hour. Wash hands with soap and water.

8. Dispose of all bagged trash in a regularly emptied or collected receptacle in accordance with local trash policies.

9. Keep an aerosol can of Lysol TM type disinfectant conveniently located (e.g., in vehicle) in the event of accidental or unexpected contact with rodent contaminated products.

10. Steam clean upholstery, shampoo with a disinfectant, or dispose of heavily contaminated items.

If you are uncertain of whether the infestation is light or heavy, consult with your safety manager or wear a respirator and googles if you have been medically cleared and fit-tested for wear.

Kit Components

  • Snap traps (10 for a normal sized room)
  • Hand sprayer (32 oz. Spritzer bottle or 2 gallon wand type sprayer)
  • Bleach or household disinfectant (e.g., LysolTM) concentrate
  • Plastic bags, small and large
  • Gloves (doubled-up rubber, latex or nitrile or reusable rubber, nitrile)

More Information
One Health Coordinator, Biological Resources Division and Office of Public Health

1201 Oakridge Drive, Suite 200, Fort Collins, CO 80525


NPS Office of Public Health, e-mail us

Dr. Danielle Buttke, Phone: 970-267-2118

Related Links

For more information from the Center for Disease Control, visit their website, here.

Learn more about the One Health concept and in practice, here.

Learn more about the Biological Resources Division by exploring their organization page, here.

Last updated: March 27, 2018