Margaret Pyror (1785-?) was the half-sister of Mary Ann M'Clintock. She lived in Waterloo with her husband George. Together they were abolition and Quaker reformers. They hosted Abby Kelley, organizer for the American Anti-Slavery Society, in their home when she traveled through the area. Margaret Pryor frequently went with Kelley as a traveling companion and bookkeeper. Pryor attended the First Woman's Rights Convention with her son, George W. Pryor, who also signed the Declaration of Sentiments.

Margaret Pryor was among a group of Hicksite Quakers who formed the new Progressive Friends or Friends of Human Progress in October of 1848. Others in the group included the M'Clintocks and Hunts and Isaac and Amy Post.