Cattle were introduced to the area's range in the 1870s and grazed primarily on public lands until the industry shifted to stock farming in response to increased private land ownership in the 1880s. Farmland along stream channels was initially irrigated by primitive, privately owned ditches until a large network of corporate canals was developed around 1880. Elevated areas were dryland farmed until drought caused the land to be returned to grazing. Historic efforts were made to mitigate the effect of droughts and floods on settlement of the region though precipitation fluctuations are common to the Plains. Fire, which occurs naturally in the Plains, was historically used as a tool for range management, hunting, and communication by native people. The US military also used fire for military tactics. Fire continues to affect the environment and lifestyles of Plains inhabitants, though recent policy supported suppression.
The Sand Creek Massacre site has been used continuously throughout the 1900s for farming and ranching, which has disturbed the site. Sand Creek is currently an intermittent stream with grass, brush, and cottonwood stands. Recent changes in vegetation include the expansion of sagebrush, introduction of non-native species, and growth of cottonwood stands along the creek banks.
Sand Creek Massacre National Historic Site was established in 2007 to preserve and protect the cultural landscape of the massacre, enhance public understanding, and minimize similar incidents in the future.