|The building at 621 River Street, in Troy, New York was built for Van Zandt, Jacobs & Company, which was one of Troy's leading cuff-and-collar companies at the time. It is locally significant in the areas of Industry and Architecture, under National Register Criteria A and C. Built at the height of the collar and cuff movement in Troy, and occupied by textile companies for nearly a century, it is a good example of the property type, --Troy Textile Factories, 1880-1920,-- as discussed in the Multiple Property Documentation Form (MPDF) --Textile Factory Buildings in Troy, New York, 1880-1920.-- It is significant in the area of Industry for its long association with the cuff-and-collar industry, which dominated industrial concerns in the city for decades. At the time the factory was in operation, Troy was a national leader in the manufacture of detachable shirt collars and cuffs. Nearly one in four residents of Troy worked in textile factories in the early 1900s. Van Zandt, Jacobs & Company operated textile factories in Troy from 1887 into the last half of the 20th century. The building at 621 River Street was built specifically for the firm, and occupied by Van Zandt, Jacobs & Company until 1923. It continued in use after that date, and was occupied by the new related company Van Zandt's, Inc. and other textile companies until the early 1980s. Architecturally, it provides a good example of mill-construction, as discussed in the MPDF. Designed by M. F. Cummings and Son, it is also locally significant as a good example of a textile factory with Romanesque Revival styling. The building is an intact, highly significant link to the industrial history of Troy.