Moose and caribou are the only members of the deer family in the Lake Clark area. Moose are found below treeline in transition areas between forest and tundra, between aquatic and terrestrial environments, and in areas that have been burned or disturbed. For more information about Alaskan moose, see the State of Alaska's wildlife notebook moose page.

The Mulchatna Caribou Herd numbers more than 100,000 animals. These caribou range through the foothill lakes and tundra plains of the western preserve. Herd size is down from an estimated 200,000 animals in 1999. More information on caribou can be found at the State of Alaska's wildlife notebook caribou page.