"Because this was the headquarters of religious administration for the entire Pimeria Alta during much of the Jesuit and Franciscan periods, it can be argued that after 1732, at least, it was also the most important church, the very hub of Pimeria Alta mission activities. Established by the Jesuits in 1691, the first mission building at Tubutama may have been destroyed in the Pima uprising of 1695.  A second adobe church was completed in 1699 and a third may have been finished in 1706.  Construction on a successor had been started in 1730 and a fifth, built of more than fifty thousand adobes, was underway in 1747 only to be destroyed in the Pima Rebellion of 1751.

"While the 1751 rebellion had reduced Jesuit missionary Jacobo Sedelmayr's house of worship to ashes, Father Luis Vivas, his successor in 1753, was able to build a new adobe church by 1764, one with two altars, a small side chapel, and a sacristy.  The first Franciscan to reside there in 1768 begged that the civil commissioner give him some old cloaks and pieces of heavy Chinese linen left by the Jesuits so he could cover the windows of the building to keep out the bats." (The Pimeria Alta, The Southwestern Mission Research Society)

Father  Antonio de los Reyes on 6 July 1772 submitted a report on the condition of the missions in the Upper and Lower Pimeria Alta.  This was his report on Tubutama as translated by Father Kieran McCarty.

The Mission at Tubutama, with one outlying mission station, lies eight leagues to the west and a little to the north of the Mission of Saric.  To the south lies the uninhabited land of Lower Pimeria and to the north are the Papagos and the other pagan nations up to the Colorado and Gila Rivers, some seventy leagues distance from this Mission.

The village at Tubutama is situated on a broad lowland of good and fertile fields where few Indians cultivate their individual fields and communally plant wheat, Indian corn, beans and other crops.  The house of the  Father Missionary is decent and roomy with an adjoining garden of quinces, pomegranates, peaches, and other trees.  The church is interiorly adorned with two altars, paintings in gilded frames, and a small side chapel.  In the sacristy are three chalices, a pyx, a ceremonial cross, ceremonial candle-holders, censer, three dishes and cruets, all of silver, vestments of every kind and color and other interesting adornments for the altar and divine services.  According to the Census Book, which I have here before me, there are forty-five married couples, twelve widowers, six widows, eighteen orphans, the number of souls in all one hundred seventy-six.

"Tubutama was perhaps the first settlement in the Pimeria Alta laid out as a fortified town with the houses built into ramparts and their doors opening onto the plaza.  the walls had only two narrow gates which were closed sundown to sunrise to protect the people and oxen enclosed inside at night.

"The interior of Tubutama's church is especially noteworthy for a transept dedicated to the Passion of Christ and which has sculptured in plaster in bas-relief on its altarpiece instruments of the Passion: crown of thorns, scourge, nails, tongs, ladder, and lances.  A sculptured serpent crawls beneath an upper niche in the same altarpiece.  This recess now holds a carved statue of Our Lady of Aránzazu, an image of the Virgin Mary as she appeared at Aránzazu in the Basque country of northern Spain.  Another unusual decorative element in Tubutama are the carved wooden pomegranates pendant from the ceiling beneath the choir loft.  Visitors are charmed by the bas-relief sculptures on the building's facade.  Not only is there a sun dial here, but so is there a pair of angels, each carrying a rooster - one of the emblems of Saint Peter.