The route to San Francisco enters Santa Clara County from the south on approximately the alignment of U.S. Highway 101, then follows the west side of the Santa Clara Valley, in the elevated land at the base of the foothills, all the way to the county line near Palo Alto.

Returning from San Francisco, the route to the East Bay exploration follows the south end of San Francisco Bay before turning north into Alameda County. 

On the return trip to Monterey, the route closely follows the eastern county line after entering from the north. It passes through rural San Antonio Valley, and then follows Skunk Hollow Gulch to the East Fork of Coyote Creek, to the main Coyote drainage and south to the vicinity of Gilroy where it rejoins the northbound route.

Federal Components
None

High Potential Route Segments
Trails within the San Francisco Bay National Wildlife Refuge (USFWS)
Trail within Henry Coe W. State Park includes Los Cruzeros, a noontime stop

Interpretive Sites
Chitactac-Adams Heritage County Park
Uvas Creek Park Preserve
Camp #92, Silvera Park
Rancho Santa Teresa Historic District/Santa Teresa County Park:
• Santa Teresa Springs
• Bernal Adobe Site
• Bernal-Joice Rancho
Camp #93, Cupertino
McClellen Ranch Park/Stevens Creek
Rancho San Antonio County Park
El Palo Alto
Greer House
Rafael Soto Home Site
Middlefield Crossing
Camp #97
Mission Santa Clara de Asís
Peña Adobe
Fernando Berreyesa Adobe
First Site of El Pueblo de San Jose de Guadalupe
Luis Maria Peralta Adobe
Plaza de Caesar Chavez
Saint Joseph Cathedral
Mountain View Shoreline Park
Sunnyvale Baylands County Park
Alviso Historic District
Jose Maria Alviso Adobe
Higuera Adobe
Camp # 103
Henry W. Coe State Park Visitor Center
Gilroy Hot Springs
Camp #104

Recreational Trail
The Santa Clara County Anza Trail Task Force coordinated closely with the Santa Clara County Trail Master Plan Advisory Committee to identify multiuse recreational trails within the historic corridor which may be marked as the Juan Bautista de Anza National Historic Trail. These are shown in the Map Supplement.

Some trail segments identified by the task force are the following:
Bay Trail segments:
• Baylands Trail in Palo Alto and Mountain View.
• Guadalupe River/Coyote Creek 
  Riparian Corridor, near Agnews area campsite. Includes San Francisco Bay Bird Observatory, San
  Francisco Bay National Wildlife Refuge, and Coyote Creek Riparian Station. 
• Sunnyvale Baylands Levee Trail Loop. A 4-mile loop. Marshes and ponds provide waterfowl and shorebird
  habitat.
• Coyote Creek Park Chain from Anderson Park in Morgan Hill to Hellyer Park in San Jose. The southern
  segment to the town of Coyote closely parallels the historic route. Trails for hikers, bikers, and 
  equestrians already exist.
• Portions of the Stevens Creek Trail
• Trail segment within Henry W. Coe State Park.
Coordination with county agencies has begun for an Anza Trail bicycle route.

Auto Route (marked)
Follow U.S. highway 101 from San Benito County to Santa Teresa Boulevard to Almaden Expressway (G8) north to Interstate 280 west to Stevens Creek Boulevard (state highway 85) to El Camino Real north to San Mateo County.

For the return from San Francisco, follow El Camino Real from San Mateo County to San Tomas Expressway, east to Montague Expressway to Interstate 680 north to Alameda County.

Auto Tour (guide book)
Follow state highway 101 north from San Benito County, to Santa Teresa Boulevard past Uvas Park Preserve, Santa Teresa County Park, and Alameda Lake Park. Take Blossom Hill Road west to Los Gatos Boulevard. Turn southwest on Los Gatos Boulevard to Los Gatos-Saratoga Road (state highway 9) and north to Saratoga-Sunnyvale Road (state highway 85) to Stevens Creek Boulevard (past De Anza College) and left to Foothill Expressway. Follow Foothill to Springer Road exit and connect with El Camino Real (state highway 82) to exit the county.

On the return from San Francisco, take El Camino Real through San Mateo County to Montague Expressway east to North Park Victoria Boulevard in Milpitas to Alameda County.

In the eastern county, the historic return route can be followed in part, but a detour is required to skirt a roadless area. Continue on Old Mines Road from Alameda County into San Antonio Valley. The road ends at private property, while the historic route continues south. Follow county road 130 and turn west over Mount Hamilton. This road leads to highway 101 south.

A loop from Gilroy allows further experience of the historic route. Exit highway 101 east on Leavesley to New Avenue north to Roop Road east which goes to Gilroy Hot Springs and Henry W. Coe State Park. Return on Cañada Road, turn left onto Pacheco Pass Highway (152 east), then turn west on Bloomfield Avenue to state highway 25 to highway 101 again.

Agency/Organization Coordination
Bay Trail Project
Bay Area Ridge Trail
Cities of
     Campbell
     Cupertino
     Gilroy
     Los Altos
     Los Altos Hills
     Los Gatos
     Milpitas
     Morgan Hill
     Mountain View
     Palo Alto
     San Jose
     Santa Clara
     Saratoga
     Sunnyvale
De Anza College/California History Center
De Anza Lancers, Inc.
Henry W. Coe State Park Trail Advisory Committee
Landowners
Los Altos Horsemen's Association
Mounted Patrol of San Mateo County
Muwekma-Ohlone Tribe
Ohlone Tribe
San Martin Horseman's Association
Santa Clara University
Santa Clara County
• Parks & Recreation Department
• Planning Department
• Transportation Agency
• Traffic Authority
• South County Trails Committee
San Jose State University
Stanford University
State of California
• Caltrans
• Coastal Conservancy
• Department of Fish and Game
• Native American Heritage Commission
• Office of Historic Preservation
• Office of Tourism
• Parks & Recreation Department 
     Henry W. Coe State Park
• State Lands Commission
U.S. Fish and Wildlife Service 
     San Francisco Bay National Wildlife Refuge