Manhattan Sites refers to six National Park Service sites located in New York's Manhattan: Castle Clinton National Monument, Federal Hall National Memorial, General Grant National Memorial, Hamilton Grange National Memorial, Saint Paul's Church National Historic Site, and Theodore Roosevelt Birthplace National Historic Site. Much of the museum collections focus on 18th century American political history, specifically on New York City's role as site of the first US Capitol, the location where Congress met for its first session and where George Washington was sworn in as the nation's first president. Nineteenth century history is represented by the birthplace and tomb of two presidents.

Significant holdings include:

See each unit for additional collection summaries.