Amistad National Recreation Area is located on the US-Mexico border near Del Rio, Texas. The park is 160 miles west of San Antonio on US 90, and about 230 miles east of Big Bend via US 90 and US 385. Access to Amistad from the north or south is via US 277/377.
Commercial airline service is not available in Del Rio. The nearest airports to Amistad National Recreation Area include: San Antonio (SAT), San Angelo (SJT), Midland (MAF), and El Paso (ELP).